DNA Binding 3/IL-10 Signaling Pathway Dendritic Cell Anergy through Inhibitor of Lung Cancer-Derived Galectin-1 Mediates
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منابع مشابه
Long non-coding RNA FOXO1 inhibits lung cancer cell growth through down-regulating PI3K/AKT signaling pathway
Objective(s): Lung cancer is one of the most common malignant tumors, which seriously threatens the health and life of the people. Recently, a novel long non-coding RNA (lncRNA) termed lncFOXO1 was found and investigated in breast cancer. However, the effect of lncFOXO1 on lung cancer is still ambiguous. The current study aimed to uncover the functions of lncFOXO1 in l...
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UNLABELLED The interaction between T cell immunoglobulin- and mucin-domain-containing molecule (Tim-3) expressed on T helper 1 (Th1) cells, and its ligand, galectin-9, negatively regulates Th1-mediated immune responses. However, it is poorly understood if and how the Tim-3/galectin-9 signaling pathway is involved in immune escape in patients with hepatocellular carcinoma (HCC). Here we studied ...
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Interleukin-10 (IL-10) has potent immunoregulatory effects on the maturation and the antigen-presenting cell (APC) function of dendritic cells (DCs). The molecular basis underlying these effects in DCs, however, is ill defined. It is well established that the transcription factor NF-kappaB is a key regulator of DC development, maturation, and APC function. This study was initiated to determine ...
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Cyclooxygenase-2 (COX-2) the enzyme at the rate-limiting step of prostanoid production is over expressed in human lung cancer. Both COX-2 and its product prostaglandin (PG) E2 underlie molecular and cellular immunosuppressive networks that contribute to the pathogenesis of non–small cell lung cancer through immune tolerance and escape from host immune surveillance. Human lung cancer cell-derive...
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تاریخ انتشار 2010